ITScriptNet versions 2.1 and higher do not require the terminal to be unlocked, and do not perform an automatic registry backup when uploading. There is no issue with cold-booting the Dolphin.
If you are using an ITScriptNet version prior to 2.1 on a Dolphin equipped with PowerTools, you must manually run the RegBackup utility after uploading your first ITB program to save the registry. If you do not, and the Dolphin is cold-booted, you must upload your ITB again to unlock the terminal.